Abstract: The overall goal of this study was to assess health professionals' perceptions of AIP management in the Central region: the case of Twifo Praso and CCMA Hospital Staff. The study employed a descriptive cross-sectional design that employed quantitative tools to investigate health professionals' perceptions of AIP management in the Central region. The study population comprised 330 health professionals from Cape Coast Metro Hospital and Twifo Praso Hospital. The Questionnaire was the main data collection instrument for the study. For the data analysis, both descriptive statistics and inferential statistics were used. It was shown that respondents effectively managed moderate AIP and that overall management competence perception on moderate AIP measured was high. Also, it was found that respondents had good management competence in severe anaemic conditions management. Further, it was discovered that respondents effectively counseled clients with AIP to access the facilities. Furthermore, the predictors such as community, household, socio-cultural, EBS, and clinical health perception explained 82.0% of the variability in effective management of AIP. Moreover, it was found that the positive clinical health perception of respondents explained 84.9% of the change seen in AIP management, and that community factors positively contributed 60.8% to AIP management. The final direct relationship established by the factors shows that environmental, behavioral, and social factors affected AIP management by 25%. The following recommendations were proffered after the findings of the study: 1) In order to effectively manage AIP, health facility management must instill in their employees positive clinical and health attitudes. 2) Management should ensure that health staff members' community and household perceptions are consistent with clinical health beliefs. This could be achieved through regular workplace surveys to gauge and realign such perceptions. 3) Management should hold regular and well-timed workshops to reorient the clinical and health beliefs of health workers in their facilities. 4) Health staff was to ensure that socio-cultural biases and beliefs were not carried out in the discharge of management of anemia in pregnancy at their facilities.