The study sought to assess operational risks management by listed commercial banks in Ghana. The study adopted the descriptive research design approach. Purposive sampling technique was adopted in the selection of one hundred and three (103) respondents for the study. The study used quantitative data from both primary and secondary sources. The primary data was collected by using questionnaire. The study adopted both the descriptive and inferential data analysis. The study found among others that the main operational risks confronting commercial banks in Ghana are people related risks, information technology related risks, and process related risks. These risks positively influence the returns of commercial banks in Ghana. As part of the mechanisms in place to curtail debilitating impacts of operational risk in commercial banks, they have internally developed operational risk management procedures which incorporate the Basel III approaches to operational risk management. These operational risk management policies were deemed effective since the banks allocated appropriate resources to their operational risk management with management ensuring bank-wide operational risk awareness environments which are supported by appropriate and adequate organizational structure and processes to implement strong risk cultures. The study therefore recommended that management develop sensitization policies to sensitize employees and give appropriate training on operational risk management to entrench risk awareness firm-wide. These trainings should not only be regular but should be in tandem with emerging issues of ORM practices and strategic compliance.