Abstract: The study investigates the relationship between exchange rate volatility and economic growth in Ghana using quarterly data from 1990 to 2012 by means of the Autoregressive Distributed Lag (ARDL) approach and the Granger causality test. The study found a unique cointegrating relationship between economic growth and exchange rate volatility. The regression results show that exchange rate volatility exerts negative and statistically significant effects on economic growth in both the short-run and long-run, suggesting that exchange rate volatility adversely influences economic growth in Ghana. The Granger causality test results revealed unidirectional causality between exchange rate volatility and economic growth, with the causality running from exchange rate volatility to economic growth. The existing literature primarily concentrates on the effects of exchange rate volatility on trade flows, investment, and inflation but fails to extensively examine its implications for Ghana's economic growth. Consequently, a comprehensive understanding of how exchange rate volatility influences the country's growth dynamics remains insufficiently explored. Therefore, there is a need for research that specifically investigates the relationship between exchange rate volatility and economic growth in Ghana, taking into account the unique characteristics of its economy, policy frameworks, and external sector dynamics.