This research evaluates the determinants influencing the adoption of health system research by health policymakers. Utilizing a non-interventional approach, the study combined both qualitative and quantitative methodologies. A descriptive cross-sectional survey was implemented. The subject pool included the Ghana Health Service (GHS) management and staff from three research centers, totaling 300 participants. This group comprised the Director-General of the GHS, the Director of the Research and Information Management System (RSIM) at the Ministry of Health (MoH), the GHS's Research Director, the heads of the three institutions, and 294 staff members. Data was processed using the SPSS software. Field findings indicated that funding does not significantly drive the use of health system research by policymakers. The term 'health research utilization' in this context refers to the application of research findings to shape health policies and practices. The process of discovering and applying knowledge is distinct, and often, this linkage is not straightforward. In Ghana, there is a significant disconnect between research discoveries and their application, with many research outcomes remaining unused in enhancing health policies and practices. The study suggests the need for more robust legislation and a clear mandate for research institutions, aimed at improving their performance in health systems research.